Ascorbic acid (Cecon, Cevalin, Vita-C)

Vitamin C has been shown to enhance the function of deferoxamine by keeping iron in a form that can be chelated. When administered with deferoxamine, allows more iron to be removed.

Dosage:

Adult

100-200 mg/d PO during deferoxamine therapy

Pediatric

3 mg/kg/d PO with SC deferoxamine infusion

Interactions:

Decreases effects of warfarin and fluphenazine; increases aspirin levels

Contraindications:

Documented hypersensitivity

Precautions:

Pregnancy

A - Fetal risk not revealed in controlled studies in humans

Precautions

Use in patients with severe iron overload may induce a short-term deterioration with acute cardiac toxicity

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