Thalassemia Faq's

Antipyretic effect through action on hypothalamic heat-regulating center. Although equal to aspirin in action, preferred because it has fewer adverse effects.

Dosage:

Adult

325-650 mg PO 30 min before transfusion

Pediatric

10-15 mg/kg/dose PO 30 min before transfusion

Interactions:

Rifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity.

Contraindications:

Documented hypersensitivity

Precautions:

Pregnancy

B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals

Precautions

Hepatotoxicity possible in people with chronic alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; APAP is contained in many OTC products, and combined use with these products may result in cumulative APAP doses exceeding recommended maximum dose.

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