Acetaminophen (Feverall, Tylenol, Tempra)
Antipyretic effect through action on hypothalamic heat-regulating center. Although equal to aspirin in action, preferred because it has fewer adverse effects.
Dosage:
Adult
325-650 mg PO 30 min before transfusion
Pediatric
10-15 mg/kg/dose PO 30 min before transfusion
Interactions:
Rifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity.
Contraindications:
Documented hypersensitivity
Precautions:
Pregnancy
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Precautions
Hepatotoxicity possible in people with chronic alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; APAP is contained in many OTC products, and combined use with these products may result in cumulative APAP doses exceeding recommended maximum dose.
