Folic acid (Folvite)
Required for DNA synthesis; therefore, patients with all conditions associated with rapid cellular turnover, such as hyperactive marrow in thalassemia, have greatly increased demand. Because use of folic acid in hemolytic anemias is extreme, deficiency states are fairly common in most of these patients. Patients who do not receive folic acid supplementation may develop megaloblastic anemia, increasing the severity of the original disease process.
Dosage:
Interactions:
Increase in seizure frequency and a decrease in subtherapeutic levels of phenytoin reported when used concurrently
Contraindications:
Documented hypersensitivity; pernicious anemia; aplastic anemia
Precautions:
Pregnancy
A - Fetal risk not revealed in controlled studies in humans
Precautions
Pregnancy category C if dose exceeds RDA; benzyl alcohol may be contained in some products as a preservative (associated with a fatal gasping syndrome in premature infants); resistance to treatment may occur in patients with alcoholism and deficiencies of other vitamins.
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