Thalassemia Faq's

An aminoglycoside. Effective against gram-negative aerobic microorganisms.

Dosage:

Adult

1-1.5 mg/kg IV q8h with normal renal function

Pediatric

6-7.5 mg/kg/d IV divided q8h

Interactions:

Coadministration with other aminoglycosides, cephalosporins, penicillins, and amphotericin B may increase nephrotoxicity; aminoglycosides enhance effects of neuromuscular blocking agents, thus prolonged respiratory depression may occur; coadministration with loop diuretics may increase auditory toxicity of aminoglycosides; possible irreversible hearing loss of varying degrees may occur (monitor regularly)

Contraindications:

Documented hypersensitivity; non–dialysis-dependent renal insufficiency

Precautions:

Pregnancy

C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus

Precautions

Narrow therapeutic index (not intended for long-term therapy); caution in renal failure (patient not on dialysis), myasthenia gravis, hypocalcemia, and conditions that depress neuromuscular transmission; adjust dose in renal impairment.

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